Silencing of SARS‐CoV‐2 with modified siRNA‐peptide dendrimer formulation

Khaitov, Musa; Nikonova, Alexandra; Shilovskiy, I.P.; V. Kozhikhova, Ksenia; Кофиади, И.А.; Vishnyakova, Lyudmila; А. Никольский, А.; Gattinger, Pia; Kovchina, V.I.; Barvinskaia, Ekaterina; Yumashev, Kirill; Smirnov, Valeriy; Maerle, Artem; Kozlov, I.B.; Shatilov, Artem; V. Timofeeva, Anastasiia; Andreev, Sergey; О. Колоскова, О.; A. Kuznetsova, Nadezhda; V. Vasina, Daria; A. Nikiforova, Maria; D. Rybalkin, Sergei; Sergeev, I.V.; Yu. Trofimov, D.; Martynov, Alexander; Berzin, Igor; А. Gushchin, Vladimir; O. Kovalchuk, A.; V. Borisevich, Sergei; Valenta, Rudolf; M. Khaitov, Rakhim; В. Скворцова, В.

doi:10.1111/all.14850

Public

Silencing of SARS‐CoV‐2 with modified siRNA‐peptide dendrimer formulation

Published in Allergy • Apr 10, 2021

Authors:

Musa Khaitov

Alexandra Nikonova

I.P. Shilovskiy

Abstract

BACKGROUND: First vaccines for prevention of Coronavirus disease 2019 (COVID-19) are becoming available but there is a huge and unmet need for specific forms of treatment. In this study we aimed to evaluate the anti-SARS-CoV-2 effect of siRNA both in vitro and in vivo. METHODS: To identify the most ...

Subject

In vitro

Small interfering RNA

Gene silencing

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