Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer’s subjects?

Daniela Femminella, Grazia; R Livingston, Nicholas; Raza, Sanara; van der Doef, Thalia; Frangou, Eleni; Love, Sharon; Busza, Gail; Calsolaro, Valeria; Carver, Stefan; Holmes, Clive; Ritchie, Craig; Lawrence, Robert; McFarlane, Brady; Tadros, George; H. Ridha, Basil; Bannister, Carol; Walker, Zuzana; Archer, Hilary; Coulthard, Elizabeth; R. Underwood, Benjamin; Prasanna, Aparna; Koranteng, Paul; Karim, Salman; Junaid, Kehinde; McGuinness, Bernadette; Peter Passmore, Anthony; Nilforooshan, Ramin; Macharouthu, Ajayverma; Donaldson, Andrew; Thacker, Simon; Russell, Gregor; Malik, Naghma; Mate, Vandana; Knight, Lucy; Kshemendran, Sajeev; Tan, Tricia; Hölscher, Christian; Harrison, John; J. Brooks, David; Ballard, Clive; Edison, Paul

doi:10.1186/s13195-021-00784-w

Public

Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer’s subjects?

Published in Alzheimer s Research & Therapy • Feb 17, 2021

Authors:

Grazia Daniela Femminella

Nicholas R Livingston

Sanara Raza

Abstract

BACKGROUND: Type 2 diabetes is a risk factor for Alzheimer's disease (AD), and AD brain shows impaired insulin signalling. The role of peripheral insulin resistance on AD aetiopathogenesis in non-diabetic patients is still debated. Here we evaluated the influence of insulin resistance on brain gluco...

Subject

Insulin resistance

Internal medicine

Medicine

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