HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation

Li, Qing; Ni, Yong; Zhang, Liren; Jiang, Runqiu; Xu, Jing; Yang, Hong; Hu, Yuanchang; Qiu, Jiannan; Pu, Liyong; Tang, Jinhai; Wang, Xuehao

doi:10.1038/s41392-020-00453-8

Public

HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation

Published in Signal Transduction and Targeted Therapy • Feb 23, 2021

Authors:

Qing Li

Yong Ni

Liren Zhang

Abstract

N6-methyladenosine (m6A), and its reader protein YTHDF1, play a pivotal role in human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy activation is one of the ways by which cancer cells survive hypoxia. However, the possible involvement of m6A modification of mRNA in hypox...

Subject

Autophagy

Gene knockdown

Cancer research

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!