Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

Voysey, Merryn; Ann Costa Clemens, Sue; A. Madhi, Shabir; Yin Weckx, Lily; M. Folegatti, Pedro; K. Aley, Parvinder; Angus, Brian; L. Baillie, Vicky; Barnabas, Shaun; Bhorat, Qasim; Bibi, Sagida; Briner, Carmen; Cicconi, Paola; Clutterbuck, Elizabeth; M. Collins, Andrea; Cutland, Clare; C. Darton, Thomas; Dheda, Keertan; Dold, Christina; Duncan, C.J.; R. W. Emary, Katherine; Ewer, Katie; Flaxman, Amy; Fairlie, Lee; N. Faust, Saul; Feng, Shuo; M. Ferreira, Daniela; Finn, Adam; Galiza, Eva; L. Goodman, Anna; Green, Catherine; Green, Christopher; Greenland, Melanie; Hill, Catherine; Hill, Helen; Hirsch, Ian; Izu, Alane; Jenkin, Daniel; C. D. Joe, Carina; Kerridge, Simon; Koen, Anthonet; Kwatra, Gaurav; Lazarus, Rajeka; Libri, Vincenzo; Lillie, Patrick; G. Marchevsky, Natalie; P. Marshall, Richard; Verena Almeida Mendes, Ana; Pı́polo Milan, Eveline; M. Minassian, Angela; McGregor, Alastair; F Mujadidi, Yama; Nana, Anusha; D. Padayachee, Sherman; J. Phillips, Daniel; Maria Pittella, Ana; Plested, Emma; M. Pollock, Katrina; Ramasamy, Maheshi; Ritchie, Adam; Robinson, Hannah; Vargas Schwarzbold, Alexandre; Smith, Darren; Song, Rinn; D. Snape, Matthew; Sprinz, Eduardo; Sutherland, Rebecca; C. Thomson, Emma; Estée Török, M.; Toshner, Mark; P. J. Turner, David; Vekemans, Johan; Villafana, Tonya; White, Thomas; J. Williams, Christopher; D. Douglas, Alexander; V. S. Hill, Adrian; Lambe, Teresa; C. Gilbert, Sarah; J. Pollard, Andrew; Aban, Marites; W.M. Abeyskera, Kushala; Aboagye, Jeremy; Adam, Matthew; Adams, Kirsty; P. Adamson, James; Adewatan, Gbadebo; Adlou, Syed; Ahmed, Khatija; Akhalwaya, Yasmeen; Akhalwaya, Saajida; Alcock, Andrew; Ali, Aabidah; Allen, Elizabeth; Allen, Lauren; B. Alvernaz, Felipe; Santos Amorim, Fabio; Sala Andrade, Claudia; Andritsou, Foteini; Anslow, Rachel; H. Arbe-Barnes, Edward; P. 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doi:10.1016/s0140-6736(21)00432-3

Public

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

Published in The Lancet • Feb 21, 2021

Authors:

Merryn Voysey

Sue Ann Costa Clemens

Shabir A. Madhi

Abstract

BACKGROUND: The ChAdOx1 nCoV-19 (AZD1222) vaccine has been approved for emergency use by the UK regulatory authority, Medicines and Healthcare products Regulatory Agency, with a regimen of two standard doses given with an interval of 4-12 weeks. The planned roll-out in the UK will involve vaccinatin...

Subject

Medicine

Immunogenicity

Placebo

Research Assistant

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