Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

Voysey, Merryn; Ann Costa Clemens, Sue; A Madhi, Shabir; Y Weckx, Lily; M Folegatti, Pedro; K Aley, Parvinder; Angus, Brian; L Baillie, Vicky; L Barnabas, Shaun; E Bhorat, Qasim; Bibi, Sagida; Briner, Carmen; Cicconi, Paola; A Clutterbuck, Elizabeth; M Collins, Andrea; L Cutland, Clare; C Darton, Thomas; Dheda, Keertan; Dold, Christina; J A Duncan, Christopher; R W Emary, Katherine; J Ewer, Katie; Flaxman, Amy; Fairlie, Lee; N Faust, Saul; Feng, Shuo; M Ferreira, Daniela; Finn, Adam; Galiza, Eva; L Goodman, Anna; M Green, Catherine; A Green, Christopher; Greenland, Melanie; Hill, Catherine; C Hill, Helen; Hirsch, Ian; Izu, Alane; Jenkin, Daniel; C D Joe, Carina; Kerridge, Simon; Koen, Anthonet; Kwatra, Gaurav; Lazarus, Rajeka; Libri, Vincenzo; J Lillie, Patrick; G Marchevsky, Natalie; P Marshall, Richard; V A Mendes, Ana; P Milan, Eveline; M Minassian, Angela; McGregor, Alastair; F Mujadidi, Yama; Nana, Anusha; D Padayachee, Sherman; J Phillips, Daniel; Pittella, Ana; Plested, Emma; M Pollock, Katrina; N Ramasamy, Maheshi; J Ritchie, Adam; Robinson, Hannah; V Schwarzbold, Alexandre; Smith, Andrew; Song, Rinn; D Snape, Matthew; Sprinz, Eduardo; K Sutherland, Rebecca; C Thomson, Emma; Estée Török, M; Toshner, Mark; P J Turner, David; Vekemans, Johan; L Villafana, Tonya; White, Thomas; J Williams, Christopher; D Douglas, Alexander; V S Hill, Adrian; Lambe, Teresa; C Gilbert, Sarah; J Pollard, Andrew; Aban, Marites; W.M. Abeyskera, Kushala; Aboagye, Jeremy; Adam, Matthew; Adams, Kirsty; P. Adamson, James; Adewatan, Gbadebo; Adlou, Syed; Ahmed, Khatija; Akhalwaya, Yasmeen; Akhalwaya, Saajida; Alcock, Andrew; Ali, Aabidah; R. Allen, Elizabeth; Allen, Lauren; B. Alvernaz, Felipe; Santos Amorim, Fabio; Sala Andrade, Claudia; Andritsou, Foteini; Anslow, Rachel; H. Arbe-Barnes, Edward; P. Ariaans, Mark; Arns, Beatriz; Arruda, Laiana; Assad, Luiza; De Almeida Azi, Paula; De Almeida Azi, Lorena; Babbage, Gavin; Bailey, Catherine; F. Baker, Kenneth; Baker, Megan; Baker, Natalie; Baker, Philip; Baleanu, Ioana; Bandeira, Danieli; Bara, Anna; A.S. Barbosa, Marcella; Barker, Debbie; D. Barlow, Gavin; Barnes, Eleanor; S. Barr, Andrew; R. Barrett, Jordan; Barrett, Jessica; Barrett, Kelly; Bates, Louise; Batten, Alexander; Beadon, Kirsten; Beales, Emily; Beckley, Rebecca; Belij-Rammerstorfer, Sandra; Bell, Jonathan; Bellamy, Duncan; Belton, Sue; Berg, Adam; Bermejo, Laura; Berrie, Eleanor; Berry, Lisa; Berzenyi, Daniella; Beveridge, Amy; R. Bewley, Kevin; Bharaj, Inderjeet; Bhikha, Sutika; E. Bhorat, Asad; E. Bhorat, Zaheda; Margreet Bijker, Else; Birch, Sarah; Birch, Gurpreet; Birchall, Kathryn; Bird, Adam; Bird, Olivia; Bisnauthsing, Karen; Bittaye, Mustapha; Blackwell, Luke; Blacow, Rachel; Bletchly, Heather; L. Blundell, Caitlin; R. Blundell, Susannah; Bodalia, Pritesh; Bolam, Emma; Boland, Elena; Bormans, Daan; Borthwick, Nicola; Bowring, Francesca; Boyd, Amy; Bradley, Penny; Brenner, Tanja; Bridges-Webb, Alice; Brown, Phillip; Brown, Claire; Brown-O'Sullivan, Charlie; Bruce, Scott; Brunt, Emily; Budd, William; A. Bulbulia, Yusuf; Bull, Melanie; Burbage, Jamie; Burn, Aileen; R. Buttigieg, Karen; Byard, Nicholas; Cabrera Puig, Ingrid; Calvert, Anna; Camara, Susana; Cao, Michelangelo; Cappuccini, Federica; Cardona, Rita; R. Cardoso, João; Carr, Melanie; W. Carroll, Miles; Carson-Stevens, Andrew; de M. Carvalho, Yasmin; R. Casey, Helen; Cashen, Paul; R.Y. Castro, Thais; Carratala Castro, Lucia; Cathie, Katrina; Cavey, Ana; Cerbino-Neto, José; Fernando F. Cezar, Luiz; Chadwick, Jim; Chanice, Chanice

doi:10.1016/s0140-6736(21)00432-3

Public

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

Shared by NobleBlocks on Mar 1, 2021 • 12:00 AM UTC

Authors:

Merryn Voysey

Sue Ann Costa Clemens

Shabir A Madhi

Research Assistant

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