Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Gharahkhani, Puya; Jorgenson, Eric; G. Hysi, Pirro; P. Khawaja, Anthony; A. Pendergrass, Sarah; Han, Xikun; Ong, Jue‐Sheng; W. Hewitt, Alex; V. Segrè, Ayellet; M. Rouhana, John; R. Hamel, Andrew; P. Igo, Robert; Choquet, Hélène; Qassim, Ayub; Shilpa Josyula, Navya; N. Cooke Bailey, Jessica; W. M. Bonnemaijer, Pieter; I. Iglesias, Adriana; M. Siggs, Owen; L. Young, Terri; Vitart, Véronique; A. H. J. Thiadens, Alberta; Karjalainen, Juha; Uebe, Steffen; B. Melles, Ronald; Saidas Nair, K.; Luben, Robert; Simcoe, Mark; Amersinghe, Nishani; J. Cree, Angela; Höhn, René; Poplawski, Alicia; Jia Chen, Li; Song Rong, Shi; Aung, Tin; N. Vithana, Eranga; Rand Allingham, R.; H. Brilliant, Murray; L. Budenz, Donald; N. Cooke Bailey, Jessica; H. Fingert, John; Gaasterland, Douglas; Gaasterland, Teresa; L. Haines, Jonathan; A. Hauser, Michael; K. Lee, Richard; R. Lichter, Paul; Liu, Yutao; Moroi, Syoko; S. Myers, Jonathan; A. Pericak‐Vance, Margaret; Realini, Anthony; Rhee, Doug; E. 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Hewitt, Alex; Japan project, Biobank; Shiono, Masaki; Misumi, Kazuo; Kaieda, Reiji; Harada, Hiromasa; Minami, Shiro; Emi, Mitsuru; Emoto, Naoya; Daida, Hiroyuki; Miyauchi, Katsumi; Murakami, Akira; Asai, Satoshi; Moriyama, Mitsuhiko; Takahashi, Yasuo; Fujioka, Tomoaki; Obara, Wataru; Mori, Seijiro; Ito, Hideki; Nagayama, Satoshi; Miki, Yoshio; Masumoto, Akihide; Yamada, Akira; Nishizawa, Yasuko; Kodama, Ken; Kutsumi, Hiromu; Sugimoto, Yoshihisa; Koretsune, Yukihiro; Kusuoka, Hideo; Yanaiag, Hideki; Nagai, Akiko; Hirata, Makoto; Kamatani, Yoichiro; Muto, Kaori; Matsuda, Koichi; Kiyohara, Yutaka; Ninomiya, Toshiharu; Tamakoshi, Akiko; Yamagata, Zentaro; Mushiroda, Taisei; Murakami, Yoshinori; Yuji, Koichiro; Furukawa, Yoichi; Zembutsu, Hitoshi; Tanaka, Toshihiro; Ohnishi, Yozo; Nakamura, Yusuke; study, FinnGen; Jalanko, Anu; Kaprio, Jaakko; Donner, Kati; Kaunisto, Mari; Mars, Nina; Dada, Alexander; Shcherban, Anastasia; Ganna, Andrea; Lehistö, Arto; Kilpeläinen, Elina; Brein, Georg; Ghazal, Awaisa; Harju, Jarmo; Pärn, Kalle; Della Briotta Parolo, Pietro; Kajanne, Risto; Lemmelä, Susanna; P. 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Bronson, Paola; John, Sally; Lahdenperä, Sanni; Eaton, Susan; Zhou, Wei; Hendolin, Minna; Tuovila, Outi; Pakkanen, Raimo; Maranville, Joseph; Usiskin, Keith; Hochfeld, Marla; M. Plenge, Robert; Yang, Robert; Biswas, Shameek; M. Greenberg, Steven; K. Laakkonen, Eija; Kononen, Juha; Paloneva, Juha; M. Kujala, Urho; Kuopio, Teijo; A. Laukkanen, Jari; Kangasniemi, Eeva; Savinainen, Kimmo; Laaksonen, Reijo; Arvas, Mikko; Ritari, Jarmo; Partanen, Jukka; Hyvärinen, Kati; Wahlfors, Tiina; S. Peterson, Andrew; Oh, Danny; Chang, Diana; Teng, Edmond; C. Strauss, Erich; Kerchner, Geoff; Chen, Hao; Chen, Hubert; L. Schutzman, Jennifer; A. Michon, John; Hunkapiller, Julie; I. McCarthy, Mark; Bowers, Natalie; Lu, Tim; Bhangale, Tushar; Pulford, David; Waterworth, Dawn; Kulkarni, Diptee; Xu, Fanli; Betts, Jo; Esparza Gordillo, Jorge; Hoffman, Joshua; Auro, Kirsi; McCarthy, Linda; Ghosh, Soumitra; Ehm, Meg; Pitkänen, Kimmo; P. Mäkelä, Tomi; Loukola, Anu; Joensuu, Heikki; Sinisalo, Juha; K. Eklund, Kari; A. Aaltonen, Lauri; Färkkilâ, Martti; Carpén, Olli; Kauppi, Paula; Tienari, Pentti; Ollila, Terhi; Tuomi, Tiinamaija; J Meretoja, Tuomo; Pitkäranta, Anne; A. Turunen, Joni; Hannula‐Jouppi, Katariina; Pikkarainen, Sampsa; Seitsonen, Sanna; Koskinen, Miika; Palomäki, Antti; O. Rinne, Juha; Metsärinne, Kaj; Elenius, Klaus; Pirilä, Laura; Koulu, Leena; Voutilainen, Markku; Juonala, Markus; Peltonen, Sirkku; Aaltonen, Vesa; Loboda, Andrey; Podgornaia, Anna; Chhibber, Aparna; Y. Chu, Audrey; S. Fox, Caroline; Diogo, Dorothée; Holzinger, Emily; D. Eicher, John; Gormley, Padhraig; Mehta, Vinay; Wang, Xulong; Kettunen, Johannes; Pylkäs, Katri; Kalaoja, Marita; K. Karjalainen, Minna; Hinttala, Reetta; Kaarteenaho, Riitta; Vainio, Seppo; Mantere, Tuomo; M. Remes, Anne; Huhtakangas, Johanna; Junttila, Juhani; Tasanen, Kaisa; Huilaja, Laura; Luodonpää, Marja; Hautala, Nina; Karihtala, Peeter; Kauppila, Saila; Harju, Terttu; Blomster, Timo; Soininen, Hilkka; T. Harvima, Ilkka; Pihlajamäki, Jussi; Kaarniranta, Kai; Pelkonen, Margit; Laakso, Markku; Hiltunen, Mikko; Kiviniemi, Mikko; Kaipiainen‐Seppänen, Oili; Auvinen, Päivi; Kälviäinen, Reetta; Julkunen, Valtteri; Mälarstig, Anders; K. Hedman, Åsa; Marshall, Catherine; D. Whelan, Christopher; Lehtonen, Heli; Parkkinen, Jaakko; Linden, Kari; Kalpala, Kirsi; Miller, Melissa; Bing, Nan; McDonough, Stefan; Chen, Xing; Hu, Xinli; Wu, Ying; Auranen, Annika; Jussila, Airi; Uusitalo‐Järvinen, Hannele; Kankaanranta, Hannu; Uusitalo, Hannu; Peltola, Jukka; Kähönen, Mika; Isomäki, Pia; Laitinen, Tarja; Salmi, Teea; J. Muslin, Anthony; Wang, Clarence; Chatelain, Clément; Xu, Ethan; Augé, Franck; Call, Kathy; Klinger, Kathy; Crohns, Marika; Gossel, Matthias; Palin, Kimmo; A. Rivas, Manuel; Siirtola, Harri; Gracia‐Tabuenca, Javier; Aslam, Tariq; Barman, Sarah; Barrett, Jenny; Bishop, Paul; Bunce, Catey; O. Carare, Roxana; Chakravarthy, Usha; Chan, Michelle; Cipriani, Valentina; Day, Alexander; Desai, Parul; Dhillon, Bal; D. Dick, Andrew; Egan, Cathy; Ennis, Sarah; J. Foster, Paul; Fruttiger, Marcus; Gallacher, John; F. Garway‐Heath, David; Whitney Gibson, Jane; Gore, Dan; A. Guggenheim, Jeremy; J. Hardcastle, Alison; Harding, Simon; Hogg, Ruth; A. Keane, Pearse; T. Khaw, Peng; P. Khawaja, Anthony; Lascaratos, Gerassimos; Lotery, Andrew; J. Luthert, Philip; MacGillivray, Tom; Mackie, Sarah; McGuinness, Bernadette; J. McKay, Gareth; McKibbin, Martin; Mitry, Danny; Moore, Tony; P. Morgan, James; Muthy, Zaynah; O’Sullivan, Eoin; G. Owen, Christopher; J. Patel, Praveen; Paterson, Euan; Pető, Tünde; Petzold, Axel; S. Rahi, Jugnoo; R. Rudnicka, Alicja; Self, Jay; Sivaprasad, Sobha; Steel, David; Stratton, Irene; G. Strouthidis, Nicholas; Sudlow, Cathie; Thaung, Caroline; Thomas, Dhanes; Trucco, Emanuele; Tufail, Adnan; A Vernon, S; C. Viswanathan, Ananth; Williams, Cathy; Williams, Katie; V. Woodside, Jayne; Yates, Max; Yip, Jennifer; Zheng, Yalin; J. Tapp, Robyn; Atan, Denize; S. F. Doney, Alex; E. Allen, Naomi; J. Littlejohns, Thomas; I. Sergouniotis, Panagiotis; C. Black, Graeme; study group, GIGA; Kanyaro, Neema; Ntomoka, Cyprian; J. Massaga, Julius; K. Ikungura, Joyce; Agee, Michelle; Aslibekyan, Stella; K. Bell, Robert; Bryc, Katarzyna; Clark, Sarah; L. Elson, Sarah; Fletez‐Brant, Kipper; Fontanillas, Pierre; A. Furlotte, Nicholas; Gandhi, Pooja; Heilbron, Karl; Hicks, Barry; A. Hinds, David; E. Huber, Karen; M. Jewett, Ethan; Jiang, Yunxuan; Kleinman, Aaron; Lin, Keng‐Han; K. Litterman, Nadia; C. McCreight, Jennifer; H. McIntyre, Matthew; F. McManus, Kimberly; L. Mountain, Joanna; V. Mozaffari, Sahar; Nandakumar, Priyanka; S. Noblin, Elizabeth; A. M. Northover, Carrie; O’Connell, Jared; J. Pitts, Steven; David Poznik, G.; Fah Sathirapongsasuti, J.; J. Shastri, Anjali; F. Shelton, Janie; Shringarpure, Suyash; Tian, Chao; Y. Tung, Joyce; J. Tunney, Robert; Vacic, Vladimir; S. Zare, Amir; Tamiya, Gen; Shiga, Yukihiro; Yamamoto, Masayuki; Nakazawa, Toru; Currant, Hannah; Birney, Ewan; Wang, Xin; Auton, Adam; K. Lupton, Michelle; G. Martin, Nicholas; Ashaye, Adeyinka; Olawoye, Olusola; Williams, Susan; Akafo, Stephen; Ramsay, Michèle; Hashimoto, Kazuki; Kamatani, Yoichiro; Akiyama, Masato; Momozawa, Yukihide; J. Foster, Paul; T. Khaw, Peng; E. Morgan, James; G. Strouthidis, Nicholas; Kraft, Peter; H. Kang, Jae; Pui Pang, Chi; Pasutto, Francesca; Mitchell, Paul; Lotery, Andrew; Palotie, Aarno; M. van Duijn, Cornelia; L. Haines, Jonathan; J. Hammond, Christopher; R. Pasquale, Louis; C. W. Klaver, Caroline; Hauser, Michael; Chuen Khor, Chiea; A. Mackey, David; Kubo, Michiaki; Cheng, Ching‐Yu; E. Craig, Jamie; MacGregor, Stuart; L. Wiggs, Janey

doi:10.1038/s41467-020-20851-4

Public

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Published in Nature Communications • Feb 24, 2021

Authors:

Puya Gharahkhani

Eric Jorgenson

Pirro G. Hysi

Abstract

Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide association studies on a total of 34,179 cases and 349,321 controls, identifying 44 previously unreported risk loci and confirm...

Subject

Biology

Genetics

Genome-wide association study

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