Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs

Li, Yan; Chen, Xin; Jin, Ronghua; Chen, Lu; Dang, Ming; Cao, Hao; Dong, Yun; Cai, Bolei; Bai, Guo; Justin Gooding, J.; Liu, Shiyu; Zou, Duohong; Zhang, Zhiyuan; Yang, Chi

doi:10.1126/sciadv.abd6740

Public

Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs

Published in Science Advances • Feb 24, 2021

Authors:

Yan Li

Xin Chen

Ronghua Jin

Abstract

Current therapeutic strategies such as angiogenic therapy and anti-inflammatory therapy for treating myocardial infarction have limited success. An effective approach may benefit from resolution of excessive inflammation combined with enhancement of angiogenesis. Here, we developed a microRNA-21-5p ...

Subject

Angiogenesis

Myocardial infarction

microRNA

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