Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

M. McDonald, Michelle; Hua Khoo, Weng; Ying Ng, Pei; Xiao, Ya; Zamerli, Jad; Thatcher, Peter; Kyaw, Wunna; Pathmanandavel, Karrnan; K. Grootveld, Abigail; Moran, Imogen; Butt, Danyal; Nguyen, Akira; P. Corr, Alexander; Warren, Sean; Biro, Maté; C. Butterfield, Natalie; E. Guilfoyle, Siobhan; Komla‐Ebri, Davide; R.G. Dack, Michael; F. Dewhurst, Hannah; G. Logan, John; Li, Yongxiao; T. Mohanty, Sindhu; M. Byrne, Niall; Terry, Rachael; K. Simic, Marija; C. Chai, Ryan; M.W. Quinn, Julian; E. Youlten, Scott; A. Pettitt, Jessica; Abi‐Hanna, David; Jain, Rohit; Weninger, Wolfgang; Lundberg, Mischa; Sun, Shuting; H. Ebetino, Frank; Timpson, Paul; Ming Lee, Woei; A. Baldock, Paul; J. Rogers, Michael; Brink, Robert; R. Williams, Graham; H. Duncan Bassett, J.; P. Kemp, John; J. Pavlos, Nathan; I. Croucher, Peter; Giang Phan, Tri

doi:10.1016/j.cell.2021.02.002

Public

Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption

Published in Cell • Feb 25, 2021

Authors:

Michelle M. McDonald

Weng Hua Khoo

Pei Ying Ng

Abstract

Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/macrophage-derived precursors that are thought to undergo apoptosis once resorption is complete. Here, by intravital imaging, we reveal that RANKL-stimulated osteoclasts have an alternative cell fate in which ...

Subject

RANKL

Multinucleate

Osteoclast

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