Haemodynamic effects of the nitroxyl donor cimlanod (BMS-986231) in chronic heart failure: a randomized trial.

NN, Lang; FA, Ahmad; JG, Cleland; CM, O'Connor; JR, Teerlink; AA, Voors; J, Taubel; AR, Hodes; M, Anwar; R, Karra; Y, Sakata; S, Ishihara; R, Senior; A, Khemka; NG, Prasad; MM, DeSouza; D, Seiffert; JY, Ye; PD, Kessler; M, Borentain; SD, Solomon; GM, Felker; JJV, McMurray

doi:10.1002/ejhf.2138

Public

Haemodynamic effects of the nitroxyl donor cimlanod (BMS-986231) in chronic heart failure: a randomized trial.

Shared by NobleBlocks on Mar 9, 2021 • 12:00 AM UTC

Authors:

Lang NN

Ahmad FA

Cleland JG

Abstract

Aims Nitroxyl provokes vasodilatation and inotropic and lusitropic effects in animals via post-translational modification of thiols. We aimed to compare effects of the nitroxyl donor cimlanod (BMS-986231) with those of nitroglycerin (NTG) or placebo on cardiac function in patients with chronic heart...

Subject

Nitrate

Echocardiography

Haemodynamics

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