Structural basis for promiscuous action of monoterpenes on TRP channels

Hong Dung Nguyen, Thi; Itoh, Satoru; Okumura, Hisashi; Tominaga, Makoto

doi:10.1038/s42003-021-01776-0

Public

Structural basis for promiscuous action of monoterpenes on TRP channels

Published in Communications Biology • Mar 5, 2021

Authors:

Thi Hong Dung Nguyen

Satoru Itoh

Hisashi Okumura

Abstract

Monoterpenes are major constituents of plant-derived essential oils and have long been widely used for therapeutic and cosmetic applications. The monoterpenes menthol and camphor are agonists or antagonists for several TRP channels such as TRPM8, TRPV1, TRPV3 and TRPA1. However, which regions within...

Subject

Transient receptor potential channel

Chemistry

Menthol

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