Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD.

Jingda, Li,; Tianqi, Wang,; Panpan, Liu,; Fuyuan, Yang,; Xudong, Wang,; Weilong, Zheng,; Wenlong, Sun,

doi:10.1039/d0fo02736g

Public

Hesperetin ameliorates hepatic oxidative stress and inflammation via the PI3K/AKT-Nrf2-ARE pathway in oleic acid-induced HepG2 cells and a rat model of high-fat diet-induced NAFLD.

Published in Food & function • May 11, 2021

Authors:

Li, Jingda

Wang, Tianqi

Liu, Panpan

Abstract

Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disease. Dietary supplementation has become a promising strategy for managing NAFLD. Hesperetin, a citrus flavonoid, is mainly found in citrus fruits (oranges, grapefruit, and lemons) and possesses multiple pharmacological...

Subject

Animals

Antioxidant Response Elements

Diet

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