The GTEx Consortium atlas of genetic regulatory effects across human tissues

Aguet, François; Anand, Shankara; Ardlie, Kristin; Gabriel, Stacey; Getz, Gad; Graubert, Aaron; Hadley, Kane; E. Handsaker, Robert; Huang, Katherine; Kashin, Seva; Li, Xiao; G. MacArthur, Daniel; R. Meier, Samuel; L. Nedzel, Jared; T. Nguyen, Duyen; V. Segrè, Ayellet; Todres, Ellen; Balliu, Brunilda; Barbeira, Alvaro; Battle, Alexis; Bonazzola, Rodrigo; Brown, Andrew; Brown, Christopher; E. Castel, Stephane; F. Conrad, Donald; J. Cotter, Daniel; J. Cox, Nancy; Das, Sayantan; M. de Goede, Olivia; T. Dermitzakis, Emmanouil; Einson, Jonah; E. Engelhardt, Barbara; Eskin, Eleazar; Eulalio, Tiffany; M. Ferraro, Nicole; D. Flynn, Elise; Frésard, Laure; R. Gamazon, Eric; Garrido-Martín, Diego; R. Gay, Nicole; J. Gloudemans, Michael; Guigó, Roderic; R. Hame, Andrew; He, Yuan; Hoffman, Paul; Hormozdiari, Farhad; Hou, Lei; Kyung Im, Hae; Jo, Brian; Kasela, Silva; Kellis, Manolis; Kim-Hellmuth, Sarah; Kwong, Alan; Lappalainen, Tuuli; Li, Xin; Liang, Yanyu; Mangul, Serghei; Mohammadi, Pejman; B. Montgomery, Stephen; Muñoz-Aguirre, Manuel; Nachun, Daniel; B. Nobel, Andrew; Oliva, Meritxell; Park, YoSon; Park, Yongjin; Parsana, Princy; Rao, Abhiram; Reverter, Ferrán; M. Rouhana, John; Sabatti, Chiara; Saha, Ashis; Stephens, Matthew; E. Stranger, Barbara; J. Strober, Benjamin; A. Teran, Nicole; Viñuela, Ana; Wang, Gao; Wen, Xiaoquan; A. Wright, Fred; Wucher, Valentin; Zou, Yuxin; G. Ferreira, Pedro; Li, Gen; Melé, Marta; Yeger‐Lotem, Esti; E. Barcus, Mary; Bradbury, Debra; Krubit, Tanya; A. McLean, Jeffrey; Qi, Liqun; Robinson, Karna; Roche, Nancy; Marie Smith, Anna; H. Sobin, Leslie; E. Tabor, David; H. Undale, Anita; Bridge, Jason; E. Brigham, Lori; A. Foster, Barbara; M. Gillard, Bryan; Hasz, Richard; Hunter, Marcus; Johns, Christopher; P. Johnson, Mark; Karasik, Ellen; Kopen, Gene; F. Leinweber, William; McDonald, Alisa; T. Moser, Michael; Myer, Kevin; D. Ramsey, Kimberley; Roe, Brian; Shad, Saboor; A. Thomas, Jeffrey; Walters, Gary; Washington, Michael; Gary Wheeler, J.; D. Jewell, Scott; C. Rohrer, Daniel; R. Valley, Dana; A. Davis, David; C. Mash, Deborah; A. Branton, Philip; K. Barker, Laura; M. Gardiner, Heather; Mosavel, Maghboeba; A. Siminoff, Laura; Flicek, Paul; Haeussler, Maximilian; Juettemann, Thomas; James Kent, W.; M. Lee, Christopher; C. Powell, Conner; R. Rosenbloom, Kate; Ruffier, Magali; Sheppard, Dan; Taylor, Kieron; J. Trevanion, Stephen; R. Zerbino, Daniel; S. Abell, Nathan; M. Akey, Joshua; Chen, Lin; Demanelis, Kathryn; A. Doherty, Jennifer; P. Feinberg, Andrew; D. Hansen, Kasper; F. Hickey, Peter; Jasmine, Farzana; Jiang, Lihua; Kaul, Rajinder; G. Kibriya, Muhammad; Billy Li, Jin; Li, Qin; Lin, Shin; E. Linder, Sandra; L. Pierce, Brandon; F. Rizzardi, Lindsay; D. Skol, Andrew; S. Smith, Kevin; Snyder, M; Stamatoyannopoulos, J; Tang, Hua; Wang, Meng; J. Carithers, Latarsha; Guan, Ping; E. Koester, Susan; Roger Little, A.; M. Moore, Helen; R. Nierras, Concepcion; K. Rao, Abhi; B. Vaught, Jimmie; Volpi, Simona

doi:10.1126/science.aaz1776

Public

The GTEx Consortium atlas of genetic regulatory effects across human tissues

Published in Science • Sep 10, 2020

Authors:

François Aguet

Shankara Anand

Kristin Ardlie

Abstract

The Genotype-Tissue Expression (GTEx) project was established to characterize genetic effects on the transcriptome across human tissues and to link these regulatory mechanisms to trait and disease associations. Here, we present analyses of the version 8 data, examining 15,201 RNA-sequencing samples ...

Subject

Biology

Gene

RNA splicing

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