Lactobacillus rhamnosus GG induces cGAS/STING- dependent type I interferon and improves response to immune checkpoint blockade.

Wei, Si,; Hua, Liang,; Jason, Bugno,; Qi, Xu,; Xingchen, Ding,; Kaiting, Yang,; Yanbin, Fu,; Ralph R, Weichselbaum,; Xin, Zhao,; Liangliang, Wang,

doi:10.1136/gutjnl-2020-323426

Public

Lactobacillus rhamnosus GG induces cGAS/STING- dependent type I interferon and improves response to immune checkpoint blockade.

Published in Gut • Mar 1, 2022

Authors:

Si, Wei

Liang, Hua

Bugno, Jason

Abstract

OBJECTIVE: Our goals were to evaluate the antitumour efficacy of Lactobacillus rhamnosus GG (LGG) in combination with immune checkpoint blockade (ICB) immunotherapies on tumour growth and to investigate the underlying mechanisms. DESIGN: We used murine models of colorectal cancer and melanoma to eva...

Subject

cancer immunobiology

gut immunology

immunology

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