Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

Muus, Christoph; D. Luecken, Malte; Eraslan, Gökcen; Sikkema, Lisa; Waghray, Avinash; Heimberg, Graham; Kobayashi, Yoshihiko; Dhaval Vaishnav, Eeshit; Subramanian, Ayshwarya; S. Smillie, Christopher; A. Jagadeesh, Karthik; Elizabeth Duong, Thu; Fiškin, Evgenij; Torlai Triglia, Elena; Ansari, Meshal; Cai, Peiwen; Lin, Brian; Buchanan, Justin; Chen, Sijia; Shu, Jian; L. Haber, Adam; Chung, Hattie; T. Montoro, Daniel; Adams, Taylor; Aliee, Hananeh; J. Allon, Samuel; Andrusivová, Žaneta; Angelidis, Ilias; Ashenberg, Orr; Baßler, Kevin; Bécavin, Christophe; Benhar, Inbal; Bergenstråhle, Joseph; Bergenstråhle, Ludvig; Bolt, Liam; Braun, Emelie; T. Bui, Linh; Callori, Steven; Chaffin, Mark; Chichelnitskiy, Evgeny; Chiou, Joshua; M. Conlon, Thomas; S. Cuoco, Michael; Cuomo, Anna; Deprez, Marie; Duclos, Grant; Fine, Denise; S. Fischer, David; Ghazanfar, Shila; Gillich, Astrid; Giotti, Bruno; Gould, Joshua; Guo, Minzhe; J. Gutierrez, Austin; C. Habermann, Arun; Harvey, Tyler; He, Peng; Hou, Xiaomeng; Hu, Lijuan; Hu, Yan; Jaiswal, Alok; Ji, Lu; Jiang, Peiyong; Kapellos, Theodoros; S. Kuo, Christin; Larsson, Ludvig; Leney-Greene, Michael; Lim, Kyungtae; Litviňuková, Monika; S. Ludwig, Leif; Lukassen, Soeren; Luo, Wendy; Maatz, Henrike; Madissoon, Elo; Mamanova, Lira; Manakongtreecheep, Kasidet; Leroy, Sylvie; H. Mayr, Christoph; Mbano, Ian; McAdams, Alexi; N. Nabhan, Ahmad; K. Nyquist, Sarah; Penland, Lolita; Poirion, Olivier; Poli, Sergio; Qi, Cancan; Queen, Rachel; Reichart, Daniel; O. Rosas, Iván; C. Schupp, Jonas; Shea, Conor; Shi, Xingyi; Sinha, Rahul; Sit, Rene; Slowikowski, Kamil; Slyper, Michal; P. Smith, Neal; Sountoulidis, Alex; Strunz, Maximilian; Sullivan, Travis; Sun, Dawei; Talavera‐López, Carlos; Tan, Peng; Tantivit, Jessica; J. Travaglini, Kyle; R. Tucker, Nathan; A. Vernon, Katherine; H. Wadsworth, Marc; Waldman, Julia; Wang, Xiuting; Xu, Ke; Yan, Wenjun; Zhao, William; G.K. Ziegler, Carly; Deutsch, Gail; Dutra, Jennifer; J. Gaulton, Kyle; Holden‐Wiltse, Jeanne; Huyck, Heidie; J. Mariani, Thomas; Misra, Ravi; Poole, Cory; Preißl, Sebastian; Pryhuber, Gloria; M. Rogers, Lisa; Sun, Xin; Wang, Allen; A. Whitsett, Jeffrey; Xu, Yan; Human Cell Atlas Lung Biological Network, The; Alladina, Jehan; E. Banovich, Nicholas; Barbry, Pascal; Beane, Jennifer; P. Bhattacharyya, Roby; E. Black, Katharine; Brāzma, Alvis; D. Campbell, Joshua; L. Cho, Josalyn; Collin, Joseph; Conrad, Christian; de Jong, Kitty; Desai, Tushar; Z. Ding, Diane; Eickelberg, Oliver; Eils, Roland; T. Ellinor, Patrick; Faiz, Alen; S. Falk, Christine; Farzan, Michael; J. Gellman, Andrew; Getz, Gad; A. Glass, Ian; Greka, Anna; Haniffa, Muzlifah; P. Hariri, Lida; Hennon, Mark; Horváth, Péter; Hübner, Norbert; T. Hung, Deborah; L. Huyck, Heidie; J. Janssen, William; Juric, Dejan; Kaminski, Naftali; Koenigshoff, M.; H. Koppelman, Gerard; A. Krasnow, Mark; A. Kropski, Jonathan; Kühnemund, Malte; Lafyatis, Robert; Lako, Majlinda; S. Lander, Eric; Lee, Haeock; E. Lenburg, Marc; Marquette, Charles‐Hugo; J. Metzger, Ross; Linnarsson, Sten; Liu, Gang; Ming Dennis Lo, Yuk; Lundeberg, Joakim; C. Marioni, John; A. Mazzilli, Sarah; D. Medoff, Benjamin; B. Meyer, Kerstin; Miao, Zhichao; V. Misharin, Alexander; C. Nawijn, Martijn; Nikolić, Marko; Noseda, Michela; Ordovás-Montañés, José; Y. Oudit, Gavin; Pe’er, Dana; E. Powell, Joseph; R. Quake, Stephen; Rajagopal, Jayaraj; Rao Tata, Purushothama; L. Rawlins, Emma; Regev, Aviv; E. Reid, Mary; A. Reyfman, Paul; Rieger‐Christ, Kimberly; Rojas, Mauricio; Rozenblatt–Rosen, Orit; Saeb‐Parsy, Kourosh; Samakovlis, Christos; R. Sanes, Joshua; B. Schiller, Herbert; L. Schultze, Joachim; F. Schwarz, Roland; V. Segrè, Ayellet; A. Seibold, Max; E. Seidman, Christine; Seidman, J.G.; K. Shalek, Alex; P. Shepherd, Douglas; Sinha, Rahul; R. Spence, Jason; Spira, Avrum; Sun, Xin; Sundström, Erik; A. Teichmann, Sarah; J. Theis, Fabian; M. Tsankov, Alexander; Vallier, Ludovic; van den Berge, Maarten; A. Van Zyl, Tave; Villani, Alexandra–Chloé; Weins, Astrid; J. Xavier, Ramnik; Önder Yildirim, Ali; Zaragosi, Laure‐Emmanuelle; Zerti, Darin; Zhang, Hongbo; Zhang, Kun; Zhang, Xiaohui

doi:10.1038/s41591-020-01227-z

Public

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics

Published in Nature Medicine • Mar 1, 2021

Authors:

Christoph Muus

Malte D. Luecken

Gökcen Eraslan

Abstract

Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL) are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry, and their expression may shed light on viral tropism and impact across the body. We assessed the cell-type-specific expression...

Subject

TMPRSS2

Biology

Immunology

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