RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming

Yin, Huilong; Zhang, Xiang; Yang, Pengyuan; Zhang, Xiaofang; Peng, Yingran; Li, Da; Yu, Yanping; Wu, Ye; Wang, Yidi; Zhang, Jinbao; Ding, Xiaochen; Wang, Xiangpeng; Yang, Angang; Zhang, Rui

doi:10.1038/s41467-021-21514-8

Public

RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming

Published in Nature Communications • Mar 2, 2021

Authors:

Huilong Yin

Xiang Zhang

Pengyuan Yang

Abstract

N6-methyladenosine (m6A) is a reversible mRNA modification that has been shown to play important roles in various biological processes. However, the roles of m6A modification in macrophages are still unknown. Here, we discover that ablation of Mettl3 in myeloid cells promotes tumour growth and metas...

Subject

Reprogramming

Cancer research

Metastasis

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