Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling

Brady, Lauren; Kriner, Michelle; M. Coleman, Ilsa; Morrissey, Colm; P. Roudier, Martine; D. True, Lawrence; Gulati, Roman; R. Plymate, Stephen; Zhou, Zoey; Birditt, Brian; Meredith, Rhonda; Geiss, Gary; L. Hoang, Margaret; Beechem, Joseph; S. Nelson, Peter

doi:10.1038/s41467-021-21615-4

Public

Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling

Published in Nature Communications • Mar 3, 2021

Authors:

Lauren Brady

Michelle Kriner

Ilsa M. Coleman

Abstract

Metastatic prostate cancer (mPC) comprises a spectrum of diverse phenotypes. However, the extent of inter- and intra-tumor heterogeneity is not established. Here we use digital spatial profiling (DSP) technology to quantitate transcript and protein abundance in spatially-distinct regions of mPCs. By...

Subject

Phenotype

Prostate cancer

Gene expression profiling

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