HP1 proteins compact DNA into mechanically and positionally stable phase separated domains

M Keenen, Madeline; A. Brown, David; D. Brennan, Lucy; Renger, Roman; Khoo, Harrison; R. Carlson, Christopher; Huang, Bo; W. Grill, Stephan; J. Narlikar, Geeta; Redding, Sy

doi:10.7554/elife.64563

Public

HP1 proteins compact DNA into mechanically and positionally stable phase separated domains

Published in eLife • Mar 4, 2021

Authors:

Madeline M Keenen

David A. Brown

Lucy D. Brennan

Abstract

In mammals, HP1-mediated heterochromatin forms positionally and mechanically stable genomic domains even though the component HP1 paralogs, HP1α, HP1β, and HP1γ, display rapid on-off dynamics. Here, we investigate whether phase-separation by HP1 proteins can explain these biological observations. Us...

Subject

Heterochromatin protein 1

Heterochromatin

DNA

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