Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia

A. Brown, Patrick; Ji, Lingyun; Xu, Xinxin; Devidas, Meenakshi; Hogan, Laura; J. Borowitz, Michael; A. Raetz, Elizabeth; Zugmaier, Gerhard; Sharon, Elad; Brooke Bernhardt, M.; Terezakis, Stephanie; Gore, Lia; A. Whitlock, James; A. Pulsipher, Michael; P. Hunger, Stephen; L. Loh, Mignon

doi:10.1001/jama.2021.0669

Public

Effect of Postreinduction Therapy Consolidation With Blinatumomab vs Chemotherapy on Disease-Free Survival in Children, Adolescents, and Young Adults With First Relapse of B-Cell Acute Lymphoblastic Leukemia

Published in JAMA • Mar 2, 2021

Authors:

Patrick A. Brown

Lingyun Ji

Xinxin Xu

Abstract

Importance: Standard chemotherapy for first relapse of B-cell acute lymphoblastic leukemia (B-ALL) in children, adolescents, and young adults is associated with high rates of severe toxicities, subsequent relapse, and death, especially for patients with early relapse (high risk) or late relapse with...

Subject

Blinatumomab

Medicine

Internal medicine

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