T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors

Yamauchi, Takayoshi; Hoki, Toshifumi; Oba, Takaaki; Jain, Vaibhav; Chen, Hongbin; Attwood, Kristopher; Battaglia, Sebastiano; George, Saby; Chatta, Gurkamal; Puzanov, Igor; Morrison, Carl; Odunsi, Kunle; H. Segal, Brahm; K. Dy, Grace; S. Ernstoff, Marc; Ito, Fumito

doi:10.1038/s41467-021-21619-0

Public

T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors

Published in Nature Communications • Mar 3, 2021

Authors:

Takayoshi Yamauchi

Toshifumi Hoki

Takaaki Oba

Abstract

Abstract Immune checkpoint inhibitors (ICI) have revolutionized treatment for various cancers; however, durable response is limited to only a subset of patients. Discovery of blood-based biomarkers that reflect dynamic change of the tumor microenvironment, and predict response to ICI, will markedly ...

Subject

CX3CR1

CD8

Immune system

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