ZFTA–RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma

Arabzade, Amir; Zhao, Yanhua; Varadharajan, Srinidhi; Chen, Hsiao-Chi; Jessa, Selin; Rivas, Bryan; J. Stuckert, Austin; Solis, Minerva; Kardian, Alisha; Tlais, Dana; J. Golbourn, Brian; J. Stanton, Ann-Catherine; San Chan, Yuen; Olson, Calla; L. Karlin, Kristen; Kong, Kathleen; Kupp, Robert; Hu, Baoli; G. Injac, Sarah; Ngo, Madeline; R. Wang, Peter; A. De León, Luz; Sahm, Felix; Kawauchi, Daisuke; M. Pfister, Stefan; Y. Lin, Charles; Courtney Hodges, H.; Singh, Irtisha; F. Westbrook, Thomas; M. Chintagumpala, Murali; M. Blaney, Susan; W. Parsons, Donald; W. Pajtler, Kristian; Agnihotri, Sameer; J. Gilbertson, Richard; Yi, Joanna; Jabado, Nada; L. Kleinman, Claudia; C. Bertrand, Kelsey; Deneen, Benjamin; C. Mack, Stephen

doi:10.1158/2159-8290.cd-20-1066

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ZFTA–RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma

Shared by NobleBlocks on Mar 19, 2021 • 12:00 AM UTC

Authors:

Amir Arabzade

Yanhua Zhao

Srinidhi Varadharajan

Abstract

Abstract More than 60% of supratentorial ependymomas harbor a ZFTA–RELA (ZRfus) gene fusion (formerly C11orf95–RELA). To study the biology of ZRfus, we developed an autochthonous mouse tumor model using in utero electroporation (IUE) of the embryonic mouse brain. Integrative epigenomic and transcrip...

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