NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases

Woo Park, Min; Woo, Hyeon; Kim, Junhyung; Han Kim, Jung; Yang, Haesung; Yoon, Sunmi; Boonpraman, Napissara; Shin Yi, Sun; Dong Yoo, Ik; Moon, Jong‐Seok

doi:10.1016/j.redox.2021.101947

Public

NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases

Published in Redox Biology • Mar 20, 2021

Authors:

Min Woo Park

Hyeon Woo

Junhyung Kim

Abstract

Oxidative stress has been implicated in the pathogenesis of Alzheimer's disease (AD). Mitochondrial dysfunction is linked to oxidative stress and reactive oxygen species (ROS) in neurotoxicity during AD. Impaired mitochondrial metabolism has been associated with mitochondrial dysfunction in brain da...

Subject

Oxidative stress

Lipid peroxidation

NOX4

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