SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-κB signaling

Liu, Huitao; Zhang, Jingjing; Xu, Xingxing; Lu, Sheng; Yang, Danlu; Xie, Changnan; Jia, Mengxian; Zhang, Wenbin; Jin, Lingting; Wang, Xiwu; Shen, Xiya; Li, Fayi; Wang, Wangfei; Bao, Xiaomei; Li, Sijia; Zhu, Minyu; Wang, Wei; Wang, Ying; Huang, Zhihui; Teng, Honglin

doi:10.7150/thno.49054

Public

SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-κB signaling

Published in Theranostics • Jan 1, 2021

Authors:

Huitao Liu

Jingjing Zhang

Xingxing Xu

Abstract

Our results indicate that SARM1-mediated prodegenerative pathway and neuroinflammation promotes the pathological progress of SCI and anti-SARM1 therapeutics are viable and promising approaches for preserving neuronal function after SCI.

Subject

Neuroinflammation

Regeneration (biology)

Spinal cord injury

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