SARS-CoV-2 infection of the oral cavity and saliva

Huang, Ni; Pérez, Paola; Kato, Takafumi; Mikami, Yu; Okuda, Kenichi; C. Gilmore, Rodney; Domínguez Conde, Cecilia; Gasmi, Billel; Stein, Sydney; Beach, Margaret; Pelayo, Eileen; O. Maldonado, José; A. P. Lafont, Bernard; Jang, Shyh-Ing; Nasir, Nadia; J. Padilla, Ricardo; A. Murrah, Valerie; Maile, Robert; Lovell, William; M. Wallet, Shannon; M. Bowman, Natalie; L. Meinig, Suzanne; C. Wolfgang, Matthew; N. Choudhury, Saibyasachi; Novotny, Mark; D. Aevermann, Brian; H. Scheuermann, Richard; Cannon, Gabrielle; W. Anderson, Carlton; E. Lee, Rhianna; T. Marchesan, Julie; Bush, Mandy; Freire, Marcelo; J. Kimple, Adam; Herr, Daniel; Rabin, Joseph; Grazioli, Alison; Das, Sanchita; French, Benjamin; Pranzatelli, Thomas; A. Chiorini, John; E. Kleiner, David; Pittaluga, Stefania; M. Hewitt, Stephen; D. Burbelo, Peter; S. Chertow, Daniel; E. Kleiner, David; Sampaio De Melo, Michelly; Dikoglu, Esra; Desar, Sabina; Ylaya, Kris; Chung, Joon‐Yong; Smith, Grace; S. Chertow, Daniel; M. Vannella, Kevin; J. Ramos-Benítez, Marcos; Ramelli, Sabrina; Samet, Shelly; L. Babyak, Ashley; Perez Valencia, Luis; Richert, Mary; Hays, Nicole; Purcell, Madeleine; Singireddy, Shreya; Wu, Jocelyn; Chung, Jean; Borth, Amy; Bowers, Kimberly; Weichold, Anne; Tran, Douglas; J. Madathil, Ronson; Krause, Eric; Herr, Daniel; Rabin, Joseph; A. Herrold, Joseph; Tabatabai, Ali; Hochberg, Eric; R. Cornachione, Christopher; R. Levine, Andrea; T. McCurdy, Michael; Saharia, Kapil; Chancer, Zack; Mazzeffi, Michael; E. Richards, Justin; W. Eagan, James; Sangwan, Yashvir; Oral and Craniofacial Biological Network, HCA; Sequeira, Inês; A. Teichmann, Sarah; J. Kimple, Adam; M. Frank, Karen; S. Lee, Janice; C. Boucher, Richard; A. Teichmann, Sarah; M. Warner, Blake; M. Byrd, Kevin

doi:10.1038/s41591-021-01296-8

Public

SARS-CoV-2 infection of the oral cavity and saliva

Published in Nature Medicine • Mar 25, 2021

Authors:

Ni Huang

Paola Pérez

Takafumi Kato

Abstract

Despite signs of infection-including taste loss, dry mouth and mucosal lesions such as ulcerations, enanthema and macules-the involvement of the oral cavity in coronavirus disease 2019 (COVID-19) is poorly understood. To address this, we generated and analyzed two single-cell RNA sequencing datasets...

Subject

Saliva

Asymptomatic

Viral shedding

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