Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles.

F, Sebastiani; Arteta M, Yanez; M, Lerche; L, Porcar; C, Lang; RA, Bragg; CS, Elmore; VR, Krishnamurthy; RA, Russell; T, Darwish; H, Pichler; S, Waldie; M, Moulin; M, Haertlein; VT, Forsyth; L, Lindfors; M, Cárdenas

doi:10.1021/acsnano.0c10064

Public

Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles.

Shared by NobleBlocks on Mar 23, 2021 • 12:00 AM UTC

Authors:

Sebastiani F

Yanez Arteta M

Lerche M

Abstract

Emerging therapeutic treatments based on the production of proteins by delivering mRNA have become increasingly important in recent times. While lipid nanoparticles (LNPs) are approved vehicles for small interfering RNA delivery, there are still challenges to use this formulation for mRNA delivery. ...

Subject

apoE

Lipid Nanoparticles

Protein Corona

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