Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles

Sebastiani, Federica; Yanez Arteta, Marianna; Lerche, Michael; Porcar, Lionel; Lång, Christian; A. Bragg, Ryan; S. Elmore, Charles; R. Krishnamurthy, Venkata; A. Russell, Robert; A. Darwish, Tamim; Pichler, Harald; Waldie, Sarah; Moulin, Martine; Haertlein, Michael; Trevor Forsyth, V.; Lindfors, Lennart; Cárdenas, Marité

doi:10.1021/acsnano.0c10064

Public

Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles

Published in ACS Nano • Mar 23, 2021

Authors:

Federica Sebastiani

Marianna Yanez Arteta

Michael Lerche

Abstract

., apolipoproteinE (ApoE). ApoE, being responsible for fat transport in the body, plays a key role in the LNP's plasma circulation time. In this work, we use small-angle neutron scattering, together with selective lipid, cholesterol, and solvent deuteration, to elucidate the structure of the LNP and...

Subject

Endosome

Apolipoprotein E

Chemistry

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!