A vaccine targeting mutant IDH1 in newly diagnosed glioma

Platten, Michael; Bunse, Lukas; Wick, Antje; Bunse, Theresa; Le Cornet, Lucian; Harting, Inga; Sahm, Felix; Sanghvi, Khwab; Leng Tan, Chin; Poschke, Isabel; Green, Edward; Justesen, Sune; A. Behrens, Geoffrey; O. Breckwoldt, Michael; Freitag, Angelika; Rother, Lisa‐Marie; Schmitt, Anita; Schnell, Oliver; Hense, J.; Misch, Martin; Krex, Dietmar; Stevanović, Stefan; Tabatabai, Ghazaleh; P. Steinbach, Joachim; Bendszus, Martin; von Deimling, Andreas; Schmitt, Michael; Wick, Wolfgang

doi:10.1038/s41586-021-03363-z

Public

A vaccine targeting mutant IDH1 in newly diagnosed glioma

Published in Nature • Mar 24, 2021

Authors:

Michael Platten

Lukas Bunse

Antje Wick

Abstract

Abstract Mutated isocitrate dehydrogenase 1 ( IDH1 ) defines a molecularly distinct subtype of diffuse glioma 1–3 . The most common IDH1 mutation in gliomas affects codon 132 and encodes IDH1(R132H), which harbours a shared clonal neoepitope that is presented on major histocompatibility complex (MHC...

Subject

IDH1

Medicine

Immune system

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