Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma

Yu, Jie; Chai, Peiwei; Xie, Minyue; Ge, Shengfang; Ruan, Jing; Fan, Xianqun; Jia, Renbing

doi:10.1186/s13059-021-02308-z

Public

Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma

Published in Genome biology • Mar 16, 2021

Authors:

Jie Yu

Peiwei Chai

Minyue Xie

Abstract

BACKGROUND: Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization. However, the role of histone lactylation in tumorigenesis remains unclear. RESULTS: Here, we show histone lactylation is e...

Subject

Biology

Carcinogenesis

Human genetics

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