Systemic Perturbations in Amine and Kynurenine Metabolism Associated with Acute SARS-CoV-2 Infection and Inflammatory Cytokine Responses

G. Lawler, Nathan; Gray, Nicola; Kimhofer, Torben; A. Boughton, Berin; Gay, Melvin; Yang, Rongchang; Morillon, Aude-Claire; Chin, Sung‐Tong; Ryan, Monique; Begum, Sofina; Bong, Sze-How; D. Coudert, Jérôme; W. Edgar, Dale; Raby, Edward; Pettersson, Sven; Richards, Toby; Holmes, Elaine; Whiley, Luke; K. Nicholson, Jeremy

doi:10.1021/acs.jproteome.1c00052

Public

Systemic Perturbations in Amine and Kynurenine Metabolism Associated with Acute SARS-CoV-2 Infection and Inflammatory Cytokine Responses

Published in Journal of Proteome Research • Mar 16, 2021

Authors:

Nathan G. Lawler

Nicola Gray

Torben Kimhofer

Abstract

High Resolution Image Download MS PowerPoint Slide We performed quantitative metabolic phenotyping of blood plasma in parallel with cytokine/chemokine analysis from participants who were either SARS-CoV-2 (+) ( n = 10) or SARS-CoV-2 (-) ( n = 49). SARS-CoV-2 positivity was associated with a unique m...

Subject

Quinolinic acid

Kynurenine

Kynurenine pathway

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