Systemic Perturbations in Amine and Kynurenine Metabolism Associated with Acute SARS-CoV-2 Infection and Inflammatory Cytokine Responses.

NG, Lawler; N, Gray; T, Kimhofer; B, Boughton; M, Gay; R, Yang; AC, Morillon; ST, Chin; M, Ryan; S, Begum; SH, Bong; JD, Coudert; D, Edgar; E, Raby; S, Pettersson; T, Richards; E, Holmes; L, Whiley; JK, Nicholson

doi:10.1021/acs.jproteome.1c00052

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Systemic Perturbations in Amine and Kynurenine Metabolism Associated with Acute SARS-CoV-2 Infection and Inflammatory Cytokine Responses.

Shared by NobleBlocks on Mar 16, 2021 • 12:00 AM UTC

Authors:

Lawler NG

Gray N

Kimhofer T

Abstract

We performed quantitative metabolic phenotyping of blood plasma in parallel with cytokine/chemokine analysis from participants who were either SARS-CoV-2 (+) (n = 10) or SARS-CoV-2 (-) (n = 49). SARS-CoV-2 positivity was associated with a unique metabolic phenotype and demonstrated a complex systemi...

Subject

Cytokines

Tryptophan

Biogenic amines

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