Neural stem cells traffic functional mitochondria via extracellular vesicles

Peruzzotti-Jametti, Luca; D. Bernstock, Joshua; M. Willis, Cory; Manferrari, Giulia; Rogall, Rebecca; Fernandez-Vizarra, Erika; C. Williamson, James; Braga, Alice; van den Bosch, Aletta; Leonardi, Tommaso; Krzak, Grzegorz; Kittel, Ágnes; Benincá, Cristiane; Vicario, Nunzio; Tan, Sisareuth; Bastos, Carlos; Bicci, Iacopo; Iraci, Nunzio; A. Smith, Jayden; Peacock, Ben; H. Muller, Karin; J. Lehner, Paul; Iren Buzas, Edit; Faria, Nuno; Zeviani, Massimo; Frezza, Christian; Brisson, Alain; J. Matheson, Nicholas; Viscomi, Carlo; Pluchino, Stefano

doi:10.1371/journal.pbio.3001166

Public

Neural stem cells traffic functional mitochondria via extracellular vesicles

Shared by NobleBlocks on Apr 7, 2021 • 12:00 AM UTC

Authors:

Luca Peruzzotti-Jametti

Joshua D. Bernstock

Cory M. Willis

Abstract

Neural stem cell (NSC) transplantation induces recovery in animal models of central nervous system (CNS) diseases. Although the replacement of lost endogenous cells was originally proposed as the primary healing mechanism of NSC grafts, it is now clear that transplanted NSCs operate via multiple mec...

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