Systems serology detects functionally distinct coronavirus antibody features in children and elderly

J. Selva, Kevin; E. van de Sandt, Carolien; M. Lemke, Melissa; Y. Lee, Christina; K. Shoffner, Suzanne; Y. Chua, Brendon; K. Davis, Samantha; H. O. Nguyen, Thi; C. Rowntree, Louise; Hensen, Luca; Koutsakos, Marios; Yi Wong, Chinn; L. Mordant, Francesca; C. Jackson, David; L. Flanagan, Katie; Crowe, Jane; Tosif, Shidan; R. Neeland, Melanie; Sutton, Philip; V. Licciardi, Paul; W. Crawford, Nigel; Cheng, Allen; L. Doolan, Denise; Amanat, Fatima; Krammer, Florian; J. Chappell, Keith; Modhiran, Naphak; Watterson, Daniel; R. Young, Paul; Shi Lee, Wen; D. Wines, Bruce; Mark Hogarth, P.; Esterbauer, Robyn; G. Kelly, Hannah; Tan, Hyon‐Xhi; A. Juno, Jennifer; K. Wheatley, Adam; J. Kent, Stephen; B. Arnold, Kelly; Kedzierska, Katherine; W. Chung, Amy

doi:10.1038/s41467-021-22236-7

Public

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

Published in Nature Communications • Apr 1, 2021

Authors:

Kevin J. Selva

Carolien E. van de Sandt

Melissa M. Lemke

Abstract

The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-2 cross-reactive immunological responses, induced by circulating human coronaviruses (hCoVs), is needed to understand such divergent clinical outcomes. Here we show analy...

Subject

Serology

Immunology

Antibody

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