Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development

Zhao, Miaomiao; Yang, Weili; Yang, Fangyuan; Zhang, Li; Huang, Weijin; Hou, Wei; Fan, Changfa; Jin, Ronghua; Feng, Yingmei; Wang, Youchun; Yang, Jin‐Kui

doi:10.1038/s41392-021-00558-8

Public

Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development

Published in Signal Transduction and Targeted Therapy • Mar 27, 2021

Authors:

Miaomiao Zhao

Weili Yang

Fangyuan Yang

Abstract

To discover new drugs to combat COVID-19, an understanding of the molecular basis of SARS-CoV-2 infection is urgently needed. Here, for the first time, we report the crucial role of cathepsin L (CTSL) in patients with COVID-19. The circulating level of CTSL was elevated after SARS-CoV-2 infection an...

Subject

Cathepsin L

In vivo

In vitro

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