Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial

R. W. Emary, Katherine; Golubchik, Tanya; K. Aley, Parvinder; V. Ariani, Cristina; Angus, Brian; Bibi, Sagida; Blane, Beth; Bonsall, David; Cicconi, Paola; Charlton, Sue; Clutterbuck, Elizabeth; M. Collins, Andrea; Cox, Tony; C. Darton, Thomas; Dold, Christina; D. Douglas, Alexander; Duncan, C.J.; Ewer, Katie; Flaxman, Amy; N. Faust, Saul; M. Ferreira, Daniela; Feng, Shuo; Finn, Adam; M. Folegatti, Pedro; Fuskova, Michelle; Galiza, Eva; L. Goodman, Anna; Green, Catherine; Green, Christopher; Greenland, Melanie; Hallis, Bassam; T. Heath, Paul; Hay, Jodie; Hill, Helen; Jenkin, Daniel; Kerridge, Simon; Lazarus, Rajeka; Libri, Vincenzo; Lillie, Patrick; Ludden, Catherine; G. Marchevsky, Natalie; M. Minassian, Angela; McGregor, Alastair; F Mujadidi, Yama; J. Phillips, Daniel; Plested, Emma; M. Pollock, Katrina; Robinson, Hannah; Smith, Darren; Song, Rinn; D. Snape, Matthew; Sutherland, Rebecca; C. Thomson, Emma; Toshner, Mark; P. J. Turner, David; Vekemans, Johan; Villafana, Tonya; J. Williams, Christopher; V. S. Hill, Adrian; Lambe, Teresa; C. Gilbert, Sarah; Voysey, Merryn; Ramasamy, Maheshi; J. Pollard, Andrew

doi:10.1016/s0140-6736(21)00628-0

Public

Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial

Published in The Lancet • Mar 30, 2021

Authors:

Katherine R. W. Emary

Tanya Golubchik

Parvinder K. Aley

Abstract

BACKGROUND: A new variant of SARS-CoV-2, B.1.1.7, emerged as the dominant cause of COVID-19 disease in the UK from November, 2020. We report a post-hoc analysis of the efficacy of the adenoviral vector vaccine, ChAdOx1 nCoV-19 (AZD1222), against this variant. METHODS: Volunteers (aged ≥18 years) who...

Subject

Medicine

Internal medicine

Vaccine efficacy

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