Acinar cell NLRP3 inflammasome and gasdermin D (GSDMD) activation mediates pyroptosis and systemic inflammation in acute pancreatitis

Gao, Lin; Dong, Xiaowu; Gong, Weijuan; Huang, Wei; Xue, Jing; Zhu, Qingtian; Ma, Nan; Chen, Weiwei; Fu, Xianghui; Gao, Xiang; Lin, Zhaoyu; Ding, Yanbing; Shi, Juanjuan; Tong, Zhihui; Liu, Tingting; Mukherjee, Rajarshi; Sutton, Robert; Lu, Guotao; Li, Weiqin

doi:10.1111/bph.15499

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Acinar cell NLRP3 inflammasome and gasdermin D (GSDMD) activation mediates pyroptosis and systemic inflammation in acute pancreatitis

Shared by NobleBlocks on May 21, 2021 • 12:00 AM UTC

Authors:

Lin Gao

Xiaowu Dong

Weijuan Gong

Abstract

Background and Purpose Pyroptosis is a lytic form of pro‐inflammatory cell death characterised as caspase 1 dependent with canonical NLRP3 inflammasome‐induced gasdermin D (GSDMD) activation. We aimed to investigate the role of acinar pyroptotic cell death in pancreatic injury and systemic inflammat...

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