Single-cell multi-omics analysis of the immune response in COVID-19

Stephenson, Emily; Reynolds, Gary; A. Botting, Rachel; J. Calero‐Nieto, Fernando; D. Morgan, Michael; Kelvin Tuong, Zewen; Bach, Karsten; Sungnak, Waradon; B. Worlock, Kaylee; Yoshida, Masahiro; Kumasaka, Natsuhiko; Kania, Katarzyna; Engelbert, Justin; Olabi, Bayanne; Stremenova Spegarova, Jarmila; K. Wilson, Nicola; Mende, Nicole; Jardine, Laura; Gardner, Louis; Goh, Issac; Horsfall, Dave; McGrath, Jim; Webb, Simone; Mather, Michael; G.H. Lindeboom, Rik; Dann, Emma; Huang, Ni; Polański, Krzysztof; Prigmore, Elena; Gothe, Florian; Scott, Jonathan; Payne, Rebecca; F. Baker, Kenneth; T. Hanrath, Aidan; Schim van der Loeff, Ina; Barr, Andrew; Sanchez-Gonzalez, Amada; Bergamaschi, Laura; Mescia, Federica; L. Barnes, Josephine; Kilich, Eliz; de Wilton, Angus; Saigal, Anita; Saleh, Aarash; M. Janes, Sam; M. Smith, Claire; Hudaa Gopee, Nusayhah; Wilson, Caroline; Coupland, Paul; Coxhead, Jonathan; Yu Kiselev, Vladimir; van Dongen, Stijn; Bacardit, Jaume; W. King, Hamish; Rostron, Anthony; John Simpson, A.; Hambleton, Sophie; Laurenti, Elisa; Lyons, Paul; B. Meyer, Kerstin; Nikolić, Marko; Duncan, C.J.; G. C. Smith, Kenneth; A. Teichmann, Sarah; R. Clatworthy, Menna; C. Marioni, John; Göttgens, Berthold; Haniffa, Muzlifah

doi:10.1038/s41591-021-01329-2

Public

Single-cell multi-omics analysis of the immune response in COVID-19

Published in Nature Medicine • Apr 20, 2021

Authors:

Emily Stephenson

Gary Reynolds

Rachel A. Botting

Abstract

Abstract Analysis of human blood immune cells provides insights into the coordinated response to viral infections such as severe acute respiratory syndrome coronavirus 2, which causes coronavirus disease 2019 (COVID-19). We performed single-cell transcriptome, surface proteome and T and B lymphocyte...

Subject

Coronavirus disease 2019 (COVID-19)

Immune system

2019-20 coronavirus outbreak

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