C5aR inhibition of nonimmune cells suppresses inflammation and maintains epithelial integrity in SARS-CoV-2–infected primary human airway epithelia

Posch, Wilfried; Vosper, Jonathan; Noureen, Asma; Zaderer, Viktoria; Witting, Christina; Bertacchi, Giulia; Gstir, Ronald; A. Filipek, Przemyslaw; K. Bonn, Günther; A. Huber, Lukas; Bellmann‐Weiler, Rosa; Lass‐Flörl, Cornelia; Wilflingseder, Doris

doi:10.1016/j.jaci.2021.03.038

Public

C5aR inhibition of nonimmune cells suppresses inflammation and maintains epithelial integrity in SARS-CoV-2–infected primary human airway epithelia

Published in Journal of Allergy and Clinical Immunology • Apr 20, 2021

Authors:

Wilfried Posch

Jonathan Vosper

Asma Noureen

Abstract

BackgroundExcessive inflammation triggered by a hitherto undescribed mechanism is a hallmark of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and is associated with enhanced pathogenicity and mortality.ObjectiveComplement hyperactivation promotes lung injury and was observe...

Subject

Inflammation

Epithelium

Respiratory epithelium

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