IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation

Amobi-McCloud, Adaobi; Muthuswamy, Ravikumar; Battaglia, Sebastiano; Yu, Han; Liu, Tao; Wang, Jianmin; Putluri, Vasanta; Kumar Singh, Prashant; Qian, Feng; Huang, Ruea-Yea; Putluri, Nagireddy; Tsuji, Takemasa; A. Lugade, Amit; Liu, Song; Odunsi, Kunle

doi:10.3389/fimmu.2021.678999

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IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation

Published in Frontiers in Immunology • Apr 16, 2021

Authors:

Adaobi Amobi-McCloud

Ravikumar Muthuswamy

Sebastiano Battaglia

Abstract

The immunoregulatory enzyme, indoleamine 2,3-dioxygenase (IDO1) and the PD-1/PD-L1 axis are potent mechanisms that impede effective anti-tumor immunity in ovarian cancer. However, whether the IDO pathway regulates PD-1 expression in T cells is currently unknown. Here we show that tumoral IDO1 expres...

Subject

Aryl hydrocarbon receptor

Ovarian cancer

Indoleamine 2

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