Fisetin inhibits lipopolysaccharide-induced inflammatory response by activating β-catenin, leading to a decrease in endotoxic shock

Menu Neelaka Molagoda, Ilandarage; Arachchige Chathuranga Chanaka Jayasingha, Jayasingha; Hyun Choi, Yung; Gedara Prasad Tharanga Jayasooriya, Rajapaksha; Kang, Chang‐Hee; Kim, Gi‐Young

doi:10.1038/s41598-021-87257-0

Public

Fisetin inhibits lipopolysaccharide-induced inflammatory response by activating β-catenin, leading to a decrease in endotoxic shock

Published in Scientific Reports • Apr 16, 2021

Authors:

Ilandarage Menu Neelaka Molagoda

Jayasingha Arachchige Chathuranga Chanaka Jayasingha

Yung Hyun Choi

Abstract

Abstract Fisetin is a naturally occurring flavonoid that possesses several pharmacological benefits including anti-inflammatory activity. However, its precise anti-inflammatory mechanism is not clear. In the present study, we found that fisetin significantly inhibited the expression of proinflammato...

Subject

Fisetin

Proinflammatory cytokine

Tumor necrosis factor alpha

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