Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1

Bastard, Paul; Orlova, Elizaveta; Sozaeva, Leila; Lévy, Romain; James, Alyssa; M. Schmitt, Monica; Ochoa, Sebastian; Kareva, Maria; Rodina, Yulia; Gervais, Adrian; Le Voyer, Tom; Rosain, Jérémie; Philippot, Quentin; Neehus, Anna‐Lena; Shaw, Elana; Migaud, Mélanie; Bizien, Lucy; Ekwall, Olov; Berg, Stefan; Beccuti, Guglielmo; Ghizzoni, Lucia; Thiriez, G.; Pavot, Arthur; Goujard, Cécile; Frémond, Marie‐Louise; Carter, Edwin; Rothenbühler, Anya; Linglart, Agnès; Mignot, B; Comte, Aurélie; Cheikh, Nathalie; Hermine, Olivier; Breivik, Lars; S. Husebye, Eystein; Humbert, S.; Rohrlich, Pierre‐Simon; Coaquette, A.; Vuoto, F.; Faure, Karine; Mahlaoui, Nizar; Kotnik, Primož; Battelino, Tadej; Trebušak Podkrajšek, Katarina; Kisand, Kai; M. N. Ferré, Elise; DiMaggio, Thomas; B. Rosen, Lindsey; D. Burbelo, Peter; McIntyre, Martin; Y. Kann, Nelli; Shcherbina, Anna; G. Pavlova, Maria; Kolodkina, Anna; M. Holland, Steven; Zhang, Shen‐Ying; J. Crow, Yanick; D. Notarangelo, Luigi; C. Su, Helen; Abel, Laurent; S. Anderson, Mark; Jouanguy, Emmanuelle; Neven, Bénédicte; Puel, Anne; Casanova, Jean‐Laurent; S. Lionakis, Michail

doi:10.1084/jem.20210554

Public

Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1

Published in The Journal of Experimental Medicine • Apr 23, 2021

Authors:

Paul Bastard

Elizaveta Orlova

Leila Sozaeva

Abstract

Patients with biallelic loss-of-function variants of AIRE suffer from autoimmune polyendocrine syndrome type-1 (APS-1) and produce a broad range of autoantibodies (auto-Abs), including circulating auto-Abs neutralizing most type I interferons (IFNs). These auto-Abs were recently reported to account ...

Subject

Coronavirus disease 2019 (COVID-19)

Pneumonia

Autoantibody

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