Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells

Carpinteiro, Alexander; Gripp, Barbara; Hoffmann, Markus; Pöhlmann, Stefan; Hoertel, Nicolas; J. Edwards, Michael; Kamler, Markus; Kornhuber, Johannes; Anne Becker, Katrin; Gulbins, Erich

doi:10.1016/j.jbc.2021.100701

Public

Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells

Published in Journal of Biological Chemistry • Jan 1, 2021

Authors:

Alexander Carpinteiro

Barbara Gripp

Markus Hoffmann

Abstract

The acid sphingomyelinase/ceramide system has been shown to be important for cellular infection with at least some viruses, for instance, rhinovirus or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Functional inhibition of the acid sphingomyelinase using tricyclic antidepressants pre...

Subject

Ambroxol

Sphingomyelin

Acid sphingomyelinase

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