The Nek2 centrosome-mitotic kinase contributes to the mesenchymal state, cell invasion, and migration of triple-negative breast cancer cells

Rivera-Rivera, Yainyrette; Marina, Mihaela; Jusino, Shirley; Lee, Mi-Young; Vélez Velázquez, Jaleisha; Chardón-Colón, Camille; Vargas, Geraldine; Padmanabhan, Jaya; Chellappan, Srikumar; I. Saavedra, Harold

doi:10.1038/s41598-021-88512-0

Public

The Nek2 centrosome-mitotic kinase contributes to the mesenchymal state, cell invasion, and migration of triple-negative breast cancer cells

Published in Scientific Reports • Apr 27, 2021

Authors:

Yainyrette Rivera-Rivera

Mihaela Marina

Shirley Jusino

Abstract

Abstract Nek2 (NIMA‐related kinase 2) is a serine/threonine-protein kinase that localizes to centrosomes and kinetochores, controlling centrosome separation, chromosome attachments to kinetochores, and the spindle assembly checkpoint. These processes prevent centrosome amplification (CA), mitotic dy...

Subject

Centrosome

Mitosis

Cancer research

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