Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer’s disease

M. Lyra e Silva, Natalia; A. Gonçalves, Rafaella; A. Pascoal, Tharick; A. S. Lima-Filho, Ricardo; de Paula França Resende, Elisa; L. M. Vieira, Erica; L. Teixeira, Antonio; C. de Souza, Leonardo; A. Peny, Julyanna; T. S. Fortuna, Juliana; C. Furigo, Isadora; Hashiguchi, Debora; S. Miya-Coreixas, Vivian; R. Clarke, Julia; F. Abisambra, Jose; M. Longo, Beatriz; Donato, Jose; E. Fraser, Paul; Rosa-Neto, Pedro; Caramelli, Paulo; T. Ferreira, Sergio; G. De Felice, Fernanda

doi:10.1038/s41398-021-01349-z

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Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer’s disease

Shared by NobleBlocks on Apr 28, 2021 • 12:00 AM UTC

Authors:

Natalia M. Lyra e Silva

Rafaella A. Gonçalves

Tharick A. Pascoal

Abstract

Abstract Alzheimer’s disease (AD) is associated with memory impairment and altered peripheral metabolism. Mounting evidence indicates that abnormal signaling in a brain-periphery metabolic axis plays a role in AD pathophysiology. The activation of pro-inflammatory pathways in the brain, including th...

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