Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease

Bergamaschi, Laura; Mescia, Federica; Turner, Lorinda; Hanson, Aimee; Kotagiri, Prasanti; J. Dunmore, Benjamin; Ruffieux, Hélène; De, Aloka; Huhn, Oisín; D. Morgan, Michael; Pereyra Gerber, Pehuén; R. Wills, Mark; Baker, Stephen; J. Calero‐Nieto, Fernando; Döffinger, Rainer; Dougan, Gordon; Elmer, Anne; Goodfellow, Ian; K. Gupta, Ravindra; Hosmillo, Myra; Hunter, Kelvin; Kingston, Nathalie; J. Lehner, Paul; J. Matheson, Nicholas; K. Nicholson, Jeremy; M. Petrunkina, Anna; Richardson, Sylvia; Saunders, Caroline; Thaventhiran, James; J. M. Toonen, Erik; P. Weekes, Michael; Göttgens, Berthold; Toshner, Mark; Hess, Christoph; R. Bradley, John; Lyons, Paul; G. C. Smith, Kenneth

doi:10.1016/j.immuni.2021.05.010

Public

Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease

Published in Immunity • May 16, 2021

Authors:

Laura Bergamaschi

Federica Mescia

Lorinda Turner

Abstract

T cell immune response, without systemic inflammation, characterized asymptomatic or mild disease. Hospitalized individuals had delayed bystander responses and systemic inflammation that was already evident near symptom onset, indicating that immunopathology may be inevitable in some individuals. Vi...

Subject

Bystander effect

Immune system

Immunology

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