An Eight-Gene Hypoxia Signature Predicts Survival in Pancreatic Cancer and Is Associated With an Immunosuppressed Tumor Microenvironment

Abou Khouzam, Raefa; Shyama Prasad Rao, R.; Hassan Venkatesh, Goutham; Ahmed Zeinelabdin, Nagwa; Buart, Stéphanie; Meylan, Maxime; Nimmakayalu, Manjunath; Terry, Stéphane; Chouaı̈b, Salem

doi:10.3389/fimmu.2021.680435

Public

An Eight-Gene Hypoxia Signature Predicts Survival in Pancreatic Cancer and Is Associated With an Immunosuppressed Tumor Microenvironment

Published in Frontiers in Immunology • May 20, 2021

Authors:

Raefa Abou Khouzam

R. Shyama Prasad Rao

Goutham Hassan Venkatesh

Abstract

Intratumoral hypoxia is a widely established element of the pancreatic tumor microenvironment (TME) promoting immune escape, tumor invasion, and progression, while contributing to treatment resistance and poor survival. Despite this critical role, hypoxia is underrepresented in molecular signatures ...

Subject

Hypoxia (environmental)

Immune system

Tumor microenvironment

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