The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι

Zhang, Yiwen; Chen, Yingshi; Li, Yuzhuang; Huang, Feng; Luo, Baohong; Yuan, Yaochang; Xia, Baijin; Ma, Xiancai; Yang, Tao; Yu, Fei; Liu, Jun; Liu, Bingfeng; Song, Zheng; Chen, Jingliang; Yan, Shumei; Wu, Liyang; Pan, Ting; Zhang, Xu; Li, Rong; Huang, Wenjing; He, Xin; Xiao, Fei; Zhang, Junsong; Zhang, Hui

doi:10.1073/pnas.2024202118

Public

The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι

Published in Proceedings of the National Academy of Sciences • May 21, 2021

Authors:

Yiwen Zhang

Yingshi Chen

Yuzhuang Li

Abstract

COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic and has claimed over 2 million lives worldwide. Although the genetic sequences of SARS-CoV and SARS-CoV-2 have high homology, the clinical and pathological characteristics of COVID-19 diffe...

Subject

Immune system

MHC class I

Biology

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