Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes

Pazoki, Raha; Vujković, Marijana; Elliott, Joshua; Εvangelou, Εvangelos; Gill, Dipender; Ghanbari, Mohsen; J. van der Most, Peter; Pinto, Rui; Wielscher, Matthias; Farlik, Matthias; Zuber, Verena; J. de Knegt, Robert; Snieder, Harold; G. Uitterlinden, André; Cohort Study, Lifelines; Marike Boezen, H.; Franke, Lude; van der Harst, Pim; Navis, Gerjan; G. Rots, Marianne; A. Swertz, Morris; H. R. Wolffenbuttel, Bruce; Wijmenga, Cisca; A. Lynch, Julie; Jiang, Xiyun; Said, Saredo; E. Kaplan, David; Min Lee, Kyung; Serper, Marina; M. Carr, Rotonya; S. Tsao, Philip; R. Atkinson, Stephen; Dehghan, Abbas; Tzoulaki, Ioanna; Arfan Ikram, M.; Herzig, Karl‐Heinz; Järvelin, Marjo‐Riitta; Z. Alizadeh, Behrooz; J. O’Donnell, Christopher; Saleheen, Danish; F. Voight, Benjamin; Chang, Kyong‐Mi; Thursz, Mark; Elliott, Paul; VA Million Veteran Program, the; K. Ballas, Zuhair; Bhushan, Sujata; J. Boyko, Edward; Cohen, David; Concato, John; Aslan, Michaela; Zhao, Hongyu; I. Constans, Joseph; J. Dell’Italia, Louis; Fayad, Joseph; Fernando, Ronald; Flórez, Hermes; A. Gaddy, Melinda; Gappy, Saib; Gibson, Gretchen; Godschalk, Michael; A. Greco, Jennifer; Gupta, Samir; Gutierrez, Salvador; Hammer, Kimberly; B. Hamner, Mark; B. Harley, John; M. Hung, Adriana; Huq, Mostaqul; A. Hurley, Robin; Iruvanti, Pran; Ivins, Douglas; J. Jacono, Frank; Jhala, Darshana; S. Kaminsky, Laurence; B. Klein, Jon; Liangpunsakul, Suthat; Lichy, Jack; Moser, Jennifer; D. Huang, Grant; Muralidhar, Sumitra; Mastorides, Stephen; O. Mathew, Roy; Mattocks, Kristin; McArdle, Rachel; N. Meyer, Paul; J. Meyer, Laurence; P. Moorman, Jonathan; R. Morgan, Timothy; Murdoch, Maureen; Okusaga, Olaoluwa; K. Oursler, Krisann; Ratcliffe, Nora; Rauchman, Michael; Brooks Robey, R.; Ross, George; J. Servatius, Richard; Sharma, Satish; E. Sherman, Scott; Sonel, Elif; Sriram, Peruvemba; Stapley, Todd; Striker, Rob; Tandon, Neeraj; Villareal, Gerardo; Wallbom, Agnes; M. Wells, John; Whittle, Jeff; A. Whooley, Mary; W.F. Wilson, Peter; V. Sun, Yan; Xu, Junzhe; Yeh, Shing‐Shing; Connor, Todd; P. Argyres, Dean; R. Hauser, Elizabeth; C. Beckham, Jean; Stephens, Brady; M. Aguayo, Samuel; K. Ahuja, Sunil; Pyarajan, Saiju; Cho, Kelly; Michael Gaziano, J.; Kinlay, Scott; T. Nguyen, Xuan‐Mai; V. Brewer, Jessica; T. Brophy, Mary; Do, Nhan; E. Humphries, Donald; E. Selva, Luis; Shayan, Shahpoor; B. Whitbourne, Stacey; Breeling, Jim; Romero, Jonathan; Ramoni, Rachel

doi:10.1038/s41467-021-22338-2

Public

Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes

Published in Nature Communications • May 10, 2021

Authors:

Raha Pazoki

Marijana Vujković

Joshua Elliott

Abstract

Serum concentration of hepatic enzymes are linked to liver dysfunction, metabolic and cardiovascular diseases. We perform genetic analysis on serum levels of alanine transaminase (ALT), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) using data on 437,438 UK Biobank participants. Rep...

Subject

Mendelian randomization

Single-nucleotide polymorphism

Alanine transaminase

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