Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma

Menzies‐Gow, Andrew; Corren, Jonathan; Bourdin, Arnaud; Chupp, Geoffrey; Israel, Elliot; E. Wechsler, Michael; E. Brightling, Christopher; M. Griffiths, Janet; Hellqvist, Åsa; Bowen, Karin; Kaur, Primal; Almqvist, Gun; Ponnarambil, Sandhia; Colice, Gene

doi:10.1056/nejmoa2034975

Public

Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma

Published in New England Journal of Medicine • May 12, 2021

Authors:

Andrew Menzies‐Gow

Jonathan Corren

Arnaud Bourdin

Abstract

BACKGROUND: Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin, an epithelial-cell-derived cytokine implicated in the pathogenesis of asthma. The efficacy and safety of tezepelumab in patients with severe, uncontrolled asthma require further assessment. METHODS: ) an...

Subject

Thymic stromal lymphopoietin

Asthma

Monoclonal antibody

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