Association Between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID-19: An Observational Multicenter Study.

N, Hoertel; M, Sánchez-Rico; E, Gulbins; J, Kornhuber; A, Carpinteiro; EJ, Lenze; AM, Reiersen; M, Abellán; la Muela P, de; R, Vernet; C, Blanco; C, Cougoule; N, Beeker; A, Neuraz; P, Gorwood; JM, Alvarado; P, Meneton; F, Limosin

doi:10.1002/cpt.2317

Public

Association Between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID-19: An Observational Multicenter Study.

Shared by NobleBlocks on Jul 2, 2021 • 12:00 AM UTC

Authors:

Hoertel N

Sánchez-Rico M

Gulbins E

Abstract

Several medications commonly used for a number of medical conditions share a property of functional inhibition of acid sphingomyelinase (ASM), or FIASMA. Preclinical and clinical evidence suggest that the ASM/ceramide system may be central to severe acute respiratory syndrome-coronavirus 2 (SARS-CoV...

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