Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy

Han, Xiaojuan; Xu, Tianshu; Fang, Qi‐Jun; Zhang, Huajun; Yue, Lijun; Hu, Gang; Sun, Lingyun

doi:10.1016/j.redox.2021.102010

Public

Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy

Published in Redox Biology • May 25, 2021

Authors:

Xiaojuan Han

Tianshu Xu

Qi‐Jun Fang

Abstract

Activated microglia are an important type of innate immune cell in the brain, and they secrete inflammatory cytokines into the extracellular milieu, exert neurotoxicity to surrounding neurons and are involved in the pathogenesis of many brain disorders. Quercetin (Qu), a natural flavonoid, is known ...

Subject

Inflammasome

Mitophagy

Microglia

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