Inflammation-Induced Histamine Impairs the Capacity of Escitalopram to Increase Hippocampal Extracellular Serotonin

Hersey, Melinda; Samaranayake, Srimal; N. Berger, Shane; Tavakoli, Navid; Mena, Sergio; Frederik Nijhout, H.; C. Reed, Michael; Best, Janet; Blakely, Randy; P. Reagan, Lawrence; Hashemi, Parastoo

doi:10.1523/jneurosci.2618-20.2021

Public

Inflammation-Induced Histamine Impairs the Capacity of Escitalopram to Increase Hippocampal Extracellular Serotonin

Published in Journal of Neuroscience • Jun 3, 2021

Authors:

Melinda Hersey

Srimal Samaranayake

Shane N. Berger

Abstract

Acute LPS-induced inflammation (1) increases CNS histamine, (2) decreases CNS serotonin (via inhibitory histamine receptors), and (3) prevents a selective serotonin reuptake inhibitor (SSRI) from effectively increasing extracellular serotonin. A targeted depletion of histamine recovers SSRI-induced ...

Subject

Serotonin

Escitalopram

Histamine

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