Clinical relevance of clonal hematopoiesis in persons aged ≥80 years

Rossi, Marianna; Meggendorfer, Manja; Zampini, Matteo; Tettamanti, Mauro; Riva, Emma; Travaglino, Erica; Bersanelli, Matteo; Mandelli, Sara; Antonella Galbussera, Alessia; Mosca, Ettore; Saba, Elena; Chiereghin, Chiara; Manes, Nicla; Milanesi, Chiara; Ubezio, Marta; Morabito, Lucio; Peano, Clelia; Soldà, Giulia; Asselta, Rosanna; Duga, Stefano; Selmi, Carlo; De Santis, Maria; Malik, Karolina; Maggioni, Giulia; Bicchieri, Marilena; Campagna, Alessia; Astrid Tentori, Cristina; Russo, Antonio; Civilini, Efrem; Allavena, Paola; Piazza, Rocco; Corrao, Giovanni; Sala, Claudia; Termanini, Alberto; Giordano, Laura; Detoma, Paolo; Malabaila, Aurelio; Sala, Luca; Rosso, Stefano; Zanetti, Roberto; Saitta, Claudia; Riva, Elena; Condorelli, Gianluigi; Passamonti, Francesco; Santoro, Armando; Solé, Françesc; Platzbecker, Uwe; Fenaux, Pierre; Bolli, Niccolò; Castellani, Gastone; Kern, Wolfgang; S. Vassiliou, George; Haferlach, Torsten; Lucca, Ugo; Giovanni Della Porta, Matteo

doi:10.1182/blood.2021011320

Public

Clinical relevance of clonal hematopoiesis in persons aged ≥80 years

Published in Blood • Jun 14, 2021

Authors:

Marianna Rossi

Manja Meggendorfer

Matteo Zampini

Abstract

Clonal hematopoiesis of indeterminate potential (CHIP) is associated with increased risk of cancers and inflammation-related diseases. This phenomenon becomes common in persons aged ≥80 years, in whom the implications of CHIP are not well defined. We performed a mutational screening in 1794 persons ...

Subject

Cytopenia

Myeloid

Myelodysplastic syndromes

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