Hippocampal-specific insulin resistance elicits behavioral despair and hippocampal dendritic atrophy

P. Reagan, Lawrence; B. Cowan, Hanson; Woodruff, J.L.; G. Piroli, Gerardo; M. Erichsen, Jennifer; EVANS, A; Burzynski, H.E.; Maxwell, Nicholas; Zoe Loyo-Rosado, Frances; A. Macht, Victoria; A. Grillo, Claudia

doi:10.1016/j.ynstr.2021.100354

Public

Hippocampal-specific insulin resistance elicits behavioral despair and hippocampal dendritic atrophy

Published in Neurobiology of Stress • Jun 16, 2021

Authors:

Lawrence P. Reagan

Hanson B. Cowan

J.L. Woodruff

Abstract

Insulin resistance is a major contributor to the neuroplasticity deficits observed in patients with metabolic disorders. However, the relative contribution of peripheral versus central insulin resistance in the development of neuroplasticity deficits remains equivocal. To distinguish between periphe...

Subject

Hippocampal formation

Dentate gyrus

Insulin resistance

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