A single-shot Lassa vaccine induces long-term immunity and protects cynomolgus monkeys against heterologous strains

Mateo, Mathieu; Reynard, Stéphanie; Journeaux, Alexandra; Germain, Clara; Hortion, Jimmy; Carnec, Xavier; Picard, Caroline; Baillet, Nicolas; Borges-Cardoso, Virginie; Merabet, Othmann; Vallvé, Audrey; Barron, Stéphane; Jourjon, Ophélie; Lacroix, Orianne; Duthey, Aurélie; Dirheimer, Manon; Jouvion, Grégory; Moreau, Pierre‐Henri; Fellmann, Lyne; Carbonnelle, Caroline; Raoul, Hervé; Tangy, Frédéric; Baize, Sylvain

doi:10.1126/scitranslmed.abf6348

Public

A single-shot Lassa vaccine induces long-term immunity and protects cynomolgus monkeys against heterologous strains

Published in Science Translational Medicine • Jun 9, 2021

Authors:

Mathieu Mateo

Stéphanie Reynard

Alexandra Journeaux

Abstract

A safe and protective Lassa virus vaccine is crucially needed in Western Africa to stem the recurrent outbreaks of Lassa virus infections in Nigeria and the emergence of Lassa virus in previously unaffected countries, such as Benin and Togo. Major challenges in developing a Lassa virus vaccine inclu...

Subject

Lassa virus

Virology

Heterologous

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